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This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: AJPH.2005.078014v1 AJPH.2005.078014v2 97/11/1981    most recent Submit a response Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Rabinoff, M. Articles by Park, C. Search for Related Content PubMed PubMed Citation Articles by Rabinoff, M. Articles by Park, C. Related Collections Tobacco Control Environmental Tobacco Smoke Health Law Health Policy Smoking Cessation

Michael Rabinoff, DO, PhD, Nicholas Caskey, PhD, Anthony Rissling, MA and Candice Park, BS

Michael Rabinoff is with the Semel Institute for Neuroscience and Human Behavior and the Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles. Nicholas Caskey is with the Semel Institute for Neuroscience and Human Behavior and the Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, and the Department of Veterans Affairs Greater Los Angeles HealthCare System, Los Angeles. Anthony Rissling is with the Department of Psychology, University of Southern California, Los Angeles. Candice Park is with the Department of Education, School of Education and Information Studies, University of California, Los Angeles.

Correspondence: Requests for reprints should be sent to Michael Rabinoff, DO, PhD, David Geffen School of Medicine, University of California, Los Angeles, 300 Medical Plaza, Suite 2251, Los Angeles, CA 90095-6968 (e-mail: mrabinoff{at}mednet.ucla.edu).

We investigated tobacco industry documents and other sources for evidence of possible pharmacological and chemical effects of tobacco additives.

Our findings indicated that more than 100 of 599 documented cigarette additives have pharmacological actions that camouflage the odor of environmental tobacco smoke emitted from cigarettes, enhance or maintain nicotine delivery, could increase the addictiveness of cigarettes, and mask symptoms and illnesses associated with smoking behaviors.

Whether such uses were specifically intended for these agents is unknown. Our results provide a clear rationale for regulatory control of tobacco additives.