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AJPH First Look, published online ahead of print Jul 27, 2006
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Assembling a Global Vaccine Development Pipeline for Infectious Diseases in the Developing World

Irina Serdobova, MBA, PhD and Marie-Paule Kieny, PhD

Irina Serdobova is with Axensus, Ltd, consultants, Cheltenham, Gloucestershire. Marie-Paule Kieny is with the Initiative for Vaccine Research, World Health Organization, Geneva, Switzerland.


Figure 1
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  		FIGURE 1—— Causes of death in children aged younger than 5 years.

Note. "Neonatal causes" includes infectious diseases (neonatal tetanus, pneumonia, meningitis, sepsis/septicemia, diarrhea and other infections during the neonatal period) as well as noncommunicable diseases (birth asphyxia, congenital abnormalities, and preterm birth). "Others" represents mortality in 10% of children aged younger than 5 years and includes causes unrelated to AIDS, diarrhea, measles, malaria, acute respiratory disease, and neonatal causes and injuries.

 

Figure 2
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  		FIGURE 2—— Driving forces for public health research and product development.

Note. The shape of the cones mimics a balloon pushed and pulled through the "eye" of the registration "needle." The arrows inside the cones represent the movement along the Push and Pull continuum. Black boxes represent potential vaccine candidates that will eventually yield 1 licensed product.

 




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