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This Article Figures Only Full Text Full Text (PDF) Data Supplement All Versions of this Article: AJPH.2007.119933v1 98/5/939    most recent Submit a response Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Doshi, P. PubMed PubMed Citation Articles by Doshi, P. Related Collections Epidemiology Immunization/Vaccines Other Infections Public Health Practice Mortality

Peter Doshi, AM

The author is in the doctoral program in History, Anthropology, Science, Technology and Society, Massachusetts Institute of Technology, Cambridge.

Correspondence: Requests for reprints should be sent to Peter Doshi, HASTS Program, E51-070, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (e-mail: pnd{at}mit.edu).

Objectives. I sought to describe trends in historical influenza mortality data in the United States since 1900 and compare pandemic with nonpandemic influenza seasons.

Methods. I compiled a database of monthly influenza-classed death rates from official US mortality tables for the years 1900 to 2004 (1905–1909 excluded), from which I calculated adjusted influenza season (July 1–June 30) mortality rates.

Results. An overall and substantial decline in influenza-classed mortality was observed during the 20th century, from an average seasonal rate of 10.2 deaths per 100 000 population in the 1940s to 0.56 per 100 000 by the 1990s. The 1918–1919 pandemic stands out as an exceptional outlier. The 1957–1958 and 1968–1969 influenza pandemic seasons, by contrast, displayed substantial overlap in both degree of mortality and timing compared with nonpandemic seasons.

Conclusions. The considerable similarity in mortality seen in pandemic and non-pandemic influenza seasons challenges common beliefs about the severity of pandemic influenza. The historical decline in influenza-classed mortality rates suggests that public health and ecological factors may play a role in influenza mortality risk. Nevertheless, the actual number of influenza-attributable deaths remains in doubt.