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This Article Full Text Full Text (PDF) All Versions of this Article: AJPH.2005.074062v1 97/6/1118    most recent Submit a response Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Manhart, L. E. Articles by Totten, P. A. Search for Related Content PubMed PubMed Citation Articles by Manhart, L. E. Articles by Totten, P. A. Related Collections Adolescent Health Epidemiology Sexual Health Women's Health

Lisa E. Manhart, PhD, King K. Holmes, MD, PhD, James P. Hughes, PhD, Laura S. Houston, MS and Patricia A. Totten, PhD

Lisa E. Manhart is with the Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle. King K. Holmes is with the Departments of Medicine, Epidemiology, and Microbiology, University of Washington, Seattle. James P. Hughes is with the Department of Biostatistics, University of Washington, Seattle. Laura S. Houston and Patricia A. Totten are with the Department of Medicine, University of Washington, Seattle. All authors are with the Center for AIDS and STDs, University of Washington, Seattle.

Correspondence: Requests for reprints should be sent to Lisa E. Manhart, PhD, University of Washington Center for AIDS and STD, 325 9th Ave, Box 359931, Seattle, WA 98104–2499 (e-mail: lmanhart{at}u.washington.edu).

Objectives. We sought to determine the prevalence of and risk factors associated with Mycoplasma genitalium infection in a nationally representative sample of young adults in the United States.

Methods. Urine specimens from 1714 women and 1218 men who participated in Wave III of the National Longitudinal Study of Adolescent Health (N=14322) were tested for M genitalium. Poststratification sampling weights were used to generate nationally representative estimates.

Results. The prevalence of M genitalium was 1.0% compared with 0.4%, 4.2%, and 2.3% for gonococcal, chlamydial, and trichomonal infections, respectively. No M genitalium–positive individuals reported symptoms of discharge. M genitalium prevalence among those who reported vaginal intercourse was 1.1% compared with 0.05% among those who did not. In multivariate analyses, M genitalium prevalence was 11 times higher among respondents who reported living with a sexual partner, 7 times higher among Blacks, and 4 times higher among those who used condoms during their last vaginal intercourse. Prevalence of M genitalium increased by 10% for each additional sexual partner.

Conclusions. M genitalium was more prevalent than Neisseria gonorrhoeae but less prevalent than Chlamydia trachomatis, and it was strongly associated with sexual activity.

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