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AJPH First Look, published online ahead of print Apr 26, 2005
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May 2005, Vol 95, No. 5 | American Journal of Public Health 900-905
© 2005 American Public Health Association
DOI: 10.2105/AJPH.2003.035485

RESEARCH AND PRACTICE

Hepatitis A–Related Mortality in California, 1989–2000: Analysis of Multiple Cause–Coded Death Data

Matthew E. Wise, MPH and Frank Sorvillo, MPH, PhD

Matthew E. Wise and Frank Sorvillo are with the Department of Epidemiology, UCLA School of Public Health, Los Angeles, Calif.

Correspondence: Requests for reprints should be sent to Matthew E. Wise, MPH, UCLA Dept of Epidemiology, Center for the Health Sciences, Rm 71–254, Box 951772, Los Angeles, CA 90095–1772 (e-mail: mawise{at}ladhs.org).

Objectives. We estimated the hepatitis A (HA) mortality rate in California, assessed demographic differences in HA-related mortality, and examined comorbidities listed on death certificates in order to provide information for health policy and planning related to HA vaccination.

Methods. We identified HA-related deaths in California from 1989 to 2000 with multiple-cause-of-death files and calculated mortality rates and rate ratios.

Results. We identified 402 HA-related deaths between 1989 and 2000; the annual age-adjusted HA-related mortality rate was 1.20 deaths per 1 million persons. Older individuals, men, Latinos, and American Indians/Alaska Natives had elevated mortality rates. Liver conditions and non-A viral hepatitis infections were more common among HA-related deaths than among all other deaths.

Conclusions. Current immunization practices should be reevaluated and the expansion of current vaccination guidelines for groups that have elevated HA-related mortality rates should be considered.






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