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June 2004, Vol 94, No. 6 | American Journal of Public Health 985-989
© 2004 American Public Health Association

RESEARCH AND PRACTICE

Vaccination and Allergic Disease: A Birth Cohort Study

Tricia M. McKeever, PhD, Sarah A. Lewis, PhD, Chris Smith, BA and Richard Hubbard, DM, Msc

The authors are with the University of Nottingham, England.

Correspondence: Requests for reprints should be sent to Tricia M. McKeever, Clinical Science Building, City Hospital, Nottingham, England, NG5 1PB (e-mail: tricia.mckeever{at}nottingham.ac.uk).

Objectives. We examined the effect of vaccination for diphtheria; polio; pertussis and tetanus; or measles, mumps, and rubella on the incidence of physician-diagnosed asthma and eczema.

Methods. We used a previously established birth cohort in the West Midlands General Practice research database.

Results. We found an association between vaccination and the development of allergic disease; however, this association was present only among children with the fewest physician visits and can be explained by this factor.

Conclusions. Our data suggest that currently recommended routine vaccinations are not a risk factor for asthma or eczema.




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