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Peter I. Folb, MD, FRCP, Ewa Bernatowska, MD, PhD, Robert Chen, MD, MA, John Clemens, MD, Alex N. O. Dodoo, PhD, MSc, MPSGH, MRPharmS, BPharm, Susan S. Ellenberg, PhD, C. Patrick Farrington, PhD, T. Jacob John, PhD, DCH, MBBS, MRCP, Paul-Henri Lambert, MD, Noni E. MacDonald, MD, MSc, BSc, Elizabeth Miller, FRCPath, MB, David Salisbury, CB, FRCP, FFPHM, Heinz-J. Schmitt, MD, Claire-Anne Siegrist, MD and Omala Wimalaratne, MD, MBBS

Peter I. Folb is with the Medical Research Council, Cape Town, South Africa. Ewa Bernatowska is with the Department of Immunology, Children’s Memorial Health Institute, Warsaw, Poland. Robert Chen is with the Immunization Safety Branch, Centers for Disease Control and Prevention, Atlanta, Ga. John Clemens is with the International Vaccine Institute, Seoul, Korea. Alex N.O. Dodoo is with the Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, Accra. Susan Ellenberg is with the Office of Biostatistics and Epidemiology, Food and Drug Administration, Rockville, Maryland. Patrick Farrington is with the Department of Statistics, Open University, Milton Keynes, England. T. Jacob John is with the Kerala State Institute of Virology and Infectious Diseases, Vellore, India. Paul-Henri Lambert and Claire-Anne Siegrist are with the World Health Organization Collaborating Centre for Neonatal Vaccinology, Centre Médical Universitaire, Geneva, Switzerland. Noni E. MacDonald is with the Department of Paediatrics, Dalhousie University, Halifax, Nova Scotia, Canada. Elizabeth Miller is with the Immunisation Department, Health Protection Agency, London, England. David Salisbury is with the Communicable Disease and Immunisation Team, Department of Health, London. Heinz-J. Schmitt is with the Center for Preventive Pediatrics, Johannes Gutenberg-Universität, Mainz, Germany. Omala Wimalaratne is with the Department of Rabies and Vaccines, Medical Research Institute, Colombo, Sri Lanka.

Correspondence: Requests for reprints should be sent to Peter I. Folb, Medical Research Council, PO Box 19070, Tygerberg, 7505, Cape Town, South Africa (e-mail: pfolb{at}mrc.ac.za).

Established in 1999, the Global Advisory Committee on Vaccine Safety advises the World Health Organization (WHO) on vaccine-related safety issues and enables WHO to respond promptly, efficiently, and with scientific rigor to issues of vaccine safety with potential global importance. The committee also assesses the implications of vaccine safety for practice worldwide and for WHO policies. We describe the principles on which the committee was established, its modus operandi, and the scope of the work undertaken, both present and future. We highlight its recent recommendations on major issues, including the purported link between the measles–mumps–rubella vaccine and autism and the safety of the mumps, influenza, yellow fever, BCG, and smallpox vaccines as well as that of thiomersal-containing vaccines.

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