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Alan H. Lockwood, MD

Alan H. Lockwood is with the Department of Veterans Affairs, Western NY Health-care System and the University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY.

Correspondence: Requests for reprints should be sent to Alan H. Lockwood, MD, Center for PET (115P), VA Western NY Healthcare System, 3495 Bailey Ave, Buffalo, NY 14215 (e-mail: ahl{at}buffalo.edu).

I reviewed ethical and scientific aspects of 6 human pesticide-dosing studies submitted to the Environmental Protection Agency (EPA) for consideration during the pesticide reregistration process. All had serious ethical or scientific deficiencies—or both—including unacceptable informed consent procedures, unmanaged financial conflicts of interest, inadequate statistical power, inappropriate test methods and endpoints, and distorted results.

Given today’s knowledge of the effects of pesticides, there is no assurance that any such study can be completely free of short-term risks, long-term risks, or both. Therefore, there is no basis for allowing pesticide studies to continue or for using them during the pesticide reregistration process. An EPA committee that is free from political and financial conflicts of interest should review this practice.

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