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G. David Batty, PhD, Martin J. Shipley, MSc, Michael G. Marmot, FRCP and George Davey Smith, MD

G. David Batty is with the Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, England. Martin J. Shipley and Michael G. Marmot are with the Department of Epidemiology and Public Health, University College London. George Davey Smith is with the Division of Epidemiology, Department of Social Medicine, University of Bristol, England.

Correspondence: Requests for reprints should be sent to G. David Batty, PhD, Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, England (e-mail: david.batty{at}lshtm.ac.uk).

Objectives. This study examined the association between leisure time physical activity and cause-specific mortality among male Whitehall Study participants with chronic bronchitis.

Methods. Rate ratios were calculated for 4 mortality outcomes, according to level of activity and baseline bronchitis status, in a 25-year follow-up of 6479 men.

Results. After multiple adjustment for potential confounding or mediating variables, activity was inversely related to all-cause, cardiovascular, coronary heart disease, and noncardiovascular mortality among men free of chronic bronchitis. Among men with bronchitis, weak, nonsignificant positive associations were observed between activity and these outcomes, with the exception of noncardiovascular mortality.

Conclusions. The suggestion of a positive activity–mortality association among individuals with chronic bronchitis—albeit weak and nonsignificant—requires further investigation.

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