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RESEARCH AND PRACTICE |
Michael Huncharek is with the Division of Radiation Oncology, Department of Clinical Oncology, Marshfield Clinic Cancer Center, Marshfield, Wis; the Meta-Analysis Research Group, Stevens Point, Wis; and St. Michael's Hospital Cancer Center, Stevens Point. Bruce Kupelnick is with the Meta-Analysis Research Group, Stevens Point.
Correspondence: Requests for reprints should be sent to Michael Huncharek, MD, MPH, FACA, Director, Meta-Analysis Research Group, 2740 Sunset Blvd, Stevens Point, WI 54481 (e-mail: metaresearch{at}hotmail.com).
Objectives. This study examined the methodology of epidemiological studies that suggest use of topical sunscreen preparations is associated with increased risk of malignant melanoma.
Methods. We pooled data from observational studies using a general variance–based meta-analytic method that employed confidence intervals (previously described). The outcome of interest was a summary relative risk (RR) reflecting the risk of melanoma associated with sunscreen use versus nonuse. Sensitivity analyses were performed when necessary to explain any observed statistical heterogeneity.
Results. Combining studies that used nonheterogeneous data yielded a summary RR of 1.01, indicating no association between sunscreen use and development of malignant melanoma.
Conclusions. The available epidemiological data do not support the existence of a relationship between topical sunscreen use and an increased risk of cutaneous malignant melanoma. (Am J Public Health. 2002;92:1173–1177)
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