| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
RESEARCH |
Fulvia Seccareccia, Francesco Dima, Cinzia Lo Noce, and Simona Giampaoli are with the Laboratory of Epidemiology and Biostatistics, Istituto Superiore di Sanità, Rome, Italy. Fabio Pannozzo is with Health Unit LT4, Latina, Italy. Anna Minoprio and Antonio Menditto are with the Laboratory of Clinical Biochemistry, Istituto Superiore di Sanità.
Correspondence: Requests for reprints should be sent to Fulvia Seccareccia, MSc, Laboratory of Epidemiology and Biostatistics, Istituto Superiore di Sanità, Viale Regina Elena, 299, I-00161 Rome, Italy (e-mail: fulvias{at}iss.it).
Objectives. This study sought to verify the independent role of heart rate in the prediction of all-cause, cardiovascular, and noncardiovascular mortality in a low-risk male population.
Methods. In an Italian population-based observational study, heart rate was measured in 2533 men, aged 40 to 69 years, between 1984 and 1993. Data on cardiovascular risk factors were collected according to standardized procedures. Vital status was updated to December 1997.
Results. Of 2533 men followed up (representing 24 457 person-years), 393 men died. Age-adjusted death rates for 5 heart rate levels showed increasing trends. The adjusted hazard rate ratios for each heart rate increment were 1.52 (95% confidence interval [CI] = 1.29, 1.78) for all-cause mortality, 1.63 (95% CI = 1.26, 2.10) for cardiovascular mortality, and 1.47 (95% CI = 1.19, 1.80) for noncardiovascular mortality. Relative risks between extreme levels were more than 2-fold for all endpoints considered.
Conclusions. Heart rate is an independent predictor of cardiovascular, noncardiovascular, and total mortality in this Italian middle-aged male population.
This article has been cited by other articles:
|
|
 |
|
  A. Tverdal, V. Hjellvik, and R. Selmer Heart rate and mortality from cardiovascular causes: a 12 year follow-up study of 379 843 men and women aged 40-45 years Eur. Heart J., November 2, 2008; 29(22): 2772 - 2781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Mathew, L. Francis, A. Kayalar, and J. Cone Obesity: Effects on Cardiovascular Disease and its Diagnosis J Am Board Fam Med, November 1, 2008; 21(6): 562 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Carney, B. Steinmeyer, K. E. Freedland, J. A. Blumenthal, P. K. Stein, W. A. Steinhoff, W. B. Howells, L. F. Berkman, L. L. Watkins, S. M. Czajkowski, et al. Nighttime Heart Rate and Survival in Depressed Patients Post Acute Myocardial Infarction Psychosom Med, September 1, 2008; 70(7): 757 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Borer Heart rate: from risk marker to risk factor Eur. Heart J. Suppl., August 1, 2008; 10(suppl_F): F2 - F6. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-C. Tardif The pivotal role of heart rate in clinical practice: from atherosclerosis to acute coronary syndrome Eur. Heart J. Suppl., August 1, 2008; 10(suppl_F): F11 - F16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Zamorano Heart rate management: a therapeutic goal throughout the cardiovascular continuum Eur. Heart J. Suppl., August 1, 2008; 10(suppl_F): F17 - F21. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cucherat Quantitative relationship between resting heart rate reduction and magnitude of clinical benefits in post-myocardial infarction: a meta-regression of randomized clinical trials Eur. Heart J., December 2, 2007; 28(24): 3012 - 3019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Cook, M. Togni, M. C. Schaub, P. Wenaweser, and O. M. Hess High heart rate: a cardiovascular risk factor? Eur. Heart J., October 2, 2006; 27(20): 2387 - 2393. [Full Text] [PDF]
|
|
|
|
 |
|
 A Black, L Murray, C Cardwell, G Davey Smith, and P McCarron Secular trends in heart rate in young adults, 1949 to 2004: analyses of cross sectional studies Heart, April 1, 2006; 92(4): 468 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. P. Savonen, T. A. Lakka, J. A. Laukkanen, P. M. Halonen, T. H. Rauramaa, J. T. Salonen, and R. Rauramaa Heart rate response during exercise test and cardiovascular mortality in middle-aged men Eur. Heart J., March 1, 2006; 27(5): 582 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Poirier, T. D. Giles, G. A. Bray, Y. Hong, J. S. Stern, F. X. Pi-Sunyer, and R. H. Eckel Obesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight Loss: An Update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease From the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism Circulation, February 14, 2006; 113(6): 898 - 918. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Shaltout and A. A. Abdel-Rahman Mechanism of Fatty Acids Induced Suppression of Cardiovascular Reflexes in Rats J. Pharmacol. Exp. Ther., September 1, 2005; 314(3): 1328 - 1337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Diaz, M. G. Bourassa, M.-C. Guertin, and J.-C. Tardif Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease Eur. Heart J., May 2, 2005; 26(10): 967 - 974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Carney, K. E. Freedland, and R. C. Veith Depression, the Autonomic Nervous System, and Coronary Heart Disease Psychosom Med, May 1, 2005; 67(Supplement_1): S29 - S33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Klein, L. E. Burke, G. A. Bray, S. Blair, D. B. Allison, X. Pi-Sunyer, Y. Hong, and R. H. Eckel Clinical Implications of Obesity With Specific Focus on Cardiovascular Disease: A Statement for Professionals From the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: Endorsed by the American College of Cardiology Foundation Circulation, November 2, 2004; 110(18): 2952 - 2967. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Salpeter, T. M. Ormiston, and E. E. Salpeter Cardiovascular Effects of {beta}-Agonists in Patients With Asthma and COPD: A Meta-Analysis Chest, June 1, 2004; 125(6): 2309 - 2321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fox Ivabradine -- a selective and specific If inhibitor: efficacy and safety in stable angina Eur. Heart J. Suppl., September 1, 2003; 5(suppl_G): G36 - G45. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Singh Diabetes, Heart Rate, and Mortality Journal of Cardiovascular Pharmacology and Therapeutics, June 1, 2002; 7(2): 117 - 129. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
