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American Journal of Public Health, Vol 91, Issue 1 138-141, Copyright © 2001 by American Public Health Association

JOURNAL ARTICLE

A novel approach to directly observed therapy for tuberculosis in an HIV-endemic area

M Desvarieux, PR Hyppolite, WD Johnson Jr and JW Pape
Division of Epidemiology, School of Public Health, Department of Medicine, School of Medicine, University of Minnesota, Minneapolis, USA. desvarieux@epi.umn.edu

OBJECTIVES: This study evaluated a novel approach to the delivery of directly observed therapy (DOT) for tuberculosis in Haiti. METHODS: A total of 194 patients (152 HIV seropositive, 42 HIV seronegative) received daily unsupervised triple-drug therapy for 4 to 8 weeks, followed by twice-weekly 2-drug therapy for the remainder of the 6-month period. DOT was deferred until initiation of the twice-weekly phase. RESULTS: A total of 169 of 194 patients (87.1%) completed the 6-month course. The program of deferred DOT had an effectiveness of 85%. Overall cost was reduced by approximately 40%. CONCLUSIONS: Flexible approaches to DOT, integrating behavioral knowledge, cost considerations, and practicality may improve completion rates and program effectiveness.


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 Am. J. Public HealthHome page
R. Long, M. Scalcini, and J. Olle-Goig
TREATMENT OF TUBERCULOSIS IN HAITI
Am J Public Health, October 1, 2001; 91(10): 1546 - 1547.
[Full Text] [PDF]

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 Am. J. Public HealthHome page
M. Desvarieux, W. D. Johnson Jr, and J. W. Pape
DESVARIEUX ET AL. RESPOND
Am J Public Health, October 1, 2001; 91(10): 1547 - 1547.
[Full Text] [PDF]


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