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Relationship of lipoprotein(a) levels to physical activity and family history of coronary heart disease.

S Martín, R Elosua, M I Covas, M Pavesi, J Vila and J Marrugat

Unitat de Lipids i Epidemiologia Cardiovascular (ULEC), Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain.

OBJECTIVES: This study evaluated the association of physical activity with serum lipoprotein(a) [La(a)] levels in individuals according to whether they had a family history of coronary heart disease (CHD). METHODS: Lp(a) levels in 332 healthy Spanish men aged 20 to 60 years were measured. Physical activity and family history of CHD were assessed. RESULTS: For men with a family history of CHD, the odds ratio for Lp(a) levels above the median value was 0.13 (95% confidence interval = 0.03, 0.50) in very active men (energy expended in physical activity > 300 kcal/day) compared with active men (energy expended in physical activity < 300 kcal/day). CONCLUSIONS: Regular daily physical activity in individuals with a family history of CHD could be useful for controlling Lp(a) levels.

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