HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Submit a response Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Simon, J A Articles by Hudes, E S Search for Related Content PubMed PubMed Citation Articles by Simon, J A Articles by Hudes, E S

Serum ascorbic acid and other correlates of gallbladder disease among US adults.

J A Simon and E S Hudes

General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco, Calif. 94121, USA.

OBJECTIVES: This study examined the correlates of clinical gallbladder disease among US adults and whether serum ascorbic acid levels are associated with a decreased prevalence of gallbladder disease. METHODS: Cross-sectional analyses of data from the Second National Health and Nutrition Examination Survey were conducted. RESULTS: A total of 384 women (8%) and 107 men (3%) reported a history of gallstone disease, and 347 women (7%) and 81 men (2%) reported a history of cholecystectomy. An inverted U-shaped relation was found between serum ascorbic acid level and clinical gallbladder disease among women but not among men. CONCLUSIONS: Ascorbic acid, which affects the catabolism of cholesterol to bile acids and, in turn, the development of gallbladder disease in experimental animals, may reduce the risk of clinical gallbladder disease in humans.

This article has been cited by other articles:

				A. Cuevas, J. F. Miquel, M. S. Reyes, S. Zanlungo, and F. Nervi Diet as a Risk Factor for Cholesterol Gallstone Disease J. Am. Coll. Nutr., June 1, 2004; 23(3): 187 - 196. [Abstract] [Full Text] [PDF]

				M Acalovschi Cholesterol gallstones: from epidemiology to prevention Postgrad. Med. J., April 1, 2001; 77(906): 221 - 229. [Full Text]

				J. A. Simon and E. S. Hudes Serum Ascorbic Acid and Gallbladder Disease Prevalence Among US Adults: The Third National Health and Nutrition Examination Survey (NHANES III) Arch Intern Med, April 10, 2000; 160(7): 931 - 936. [Abstract] [Full Text] [PDF]

				K. J. Vega and D. E. Johnston Exercise and the Gallbladder N. Engl. J. Med., September 9, 1999; 341(11): 836 - 837. [Full Text]

				J. A. Simon and E. S. Hudes Relation of Serum Ascorbic Acid to Serum Vitamin B12, Serum Ferritin, and Kidney Stones in US Adults Arch Intern Med, March 22, 1999; 159(6): 619 - 624. [Abstract] [Full Text] [PDF]