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American Journal of Public Health, Vol. 84, Issue 7 1144-1148, Copyright © 1994 by American Public Health Association

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A decision-analytic approach to postexposure rabies prophylaxis.

S B Cantor, R D Clover and R F Thompson

Department of Family Medicine, University of Texas Medical Branch at Galveston 77555-0853.

The risks and benefits of postexposure rabies prophylaxis were analyzed from clinical and economic perspectives. A decision-analytic model was constructed by using probability and outcome data from the literature and the state health department. Health outcomes were measured in quality-adjusted life years. In the base case (overweight adult male), treatment is optimal when the probability of animal rabidity is greater than 1 in 2000. Sensitivity analysis showed robustness in the treatment decision; however, the incremental cost-effectiveness ratio ($140,000/quality-adjusted life year) is sensitive to the rabidity probability. Treatment is optimal from the patient's perspective; however, it may not be cost-effective when the probability of rabidity is low.


Related articles in AJPH:

Postexposure rabies prophylaxis. 1. Experience with a computerized algorithm.
V M Dato, F E Sorhage, and K C Spitalny
AJPH 1995 85: 1020-1021. [PDF]  

Postexposure rabies prophylaxis. 2. Expanding the treatment model.
S A Llorens and D Neuhauser
AJPH 1995 85: 1020-1021. [PDF]  



This article has been cited by other articles:


Home page
 Arch Pediatr Adolesc MedHome page
A. C. Caviness, G. J. Demmler, J. M. Swint, and S. B. Cantor
Cost-effectiveness Analysis of Herpes Simplex Virus Testing and Treatment Strategies in Febrile Neonates
Arch Pediatr Adolesc Med, July 1, 2008; 162(7): 665 - 674.
[Abstract] [Full Text] [PDF]


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Copyright © 1994 by the American Public Health Association