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American Journal of Public Health, Vol. 83, Issue 9 1335-1338, Copyright © 1993 by American Public Health Association

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Cotinine concentrations in semen, urine, and blood of smokers and nonsmokers.

M F Vine, B S Hulka, B H Margolin, Y K Truong, P C Hu, M M Schramm, J D Griffith, M McCann and R B Everson

Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599-7400.

Cotinine levels in the semen, urine, and blood of 88 male smokers and nonsmokers, aged 18 to 35, were analyzed via radioimmunoassay. Detectable cotinine levels were found in all three body fluids, and cotinine levels in all three fluids were highly correlated. Cotinine levels in semen and blood were of similar magnitude; cotinine levels in urine were an order of magnitude or more higher. In all three fluids, cotinine levels increased with an increase in cigarette smoke exposure.




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