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American Journal of Public Health, Vol. 77, Issue 5 623-625, Copyright © 1987 by American Public Health Association

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Maternal cigarette smoking and oral clefts: a population-based study.

M J Khoury, A Weinstein, S Panny, N A Holtzman, P K Lindsay, K Farrel and M Eisenberg

Analyses of 1984 data from the Maryland Birth Defects Reporting and Information System indicate that mothers of infants with oral clefts (cleft lip with or without cleft palate; and cleft palate) smoked more during pregnancy than mothers of infants with other defects (odds ratio OR of 2.56 and 2.39, respectively). There was a dose-response relation between the daily amount smoked and the risk of clefting. Adjustment for available confounding variables did not account for the association between smoking and oral clefts.




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